Are Chloroplasts Found In Most Animal Cells
Med Sci Monit. 2015; 21: 2073–2078.
Mitochondria, Chloroplasts in Animal and Institute Cells: Significance of Conformational Matching
Received 2015 May 25; Accepted 2015 Jun 26.
Abstract
Many commonalities between chloroplasts and mitochondria exist, thereby suggesting a common origin via a bacterial ancestor capable of enhanced ATP-dependent energy production functionally linked to cellular respiration and photosynthesis. Accordingly, the molecular evolution/retention of the catalytic Qo quinol oxidation site of cytochrome b complexes equally the tetrapeptide PEWY sequence functionally underlies the common retention of a chemiosmotic proton slope mechanism for ATP synthesis in cellular respiration and photosynthesis. Furthermore, the dual regulatory targeting of mitochondrial and chloroplast gene expression past mitochondrial transcription termination cistron (MTERF) proteins to promote optimal energy production and oxygen consumption further advances these evolutionary contentions. Every bit a functional consequence of enhanced oxygen utilization and production, significant levels of reactive oxygen species (ROS) may be generated within mitochondria and chloroplasts, which may effectively compromise cellular free energy production following prolonged stress/inflammationary conditions. Interestingly, both types of organelles have been identified in selected fauna cells, well-nigh notably specialized digestive cells lining the gut of several species of Sacoglossan sea slugs. Termed kleptoplasty or kleptoplastic endosymbiosis, functional chloroplasts from algal food sources are internalized and stored within digestive cells to provide the host with dual energy sources derived from mitochondrial and photosynthetic processes. Recently, the ascertainment of internalized algae within embryonic tissues of the spotted salamander strongly suggest that developmental processes within a vertebrate organism may crave photosynthetic endosymbiosis every bit an internal regulator. The dual presence of mitochondria and functional chloroplasts within specialized fauna cells indicates a high degree of biochemical identity, stereoselectivity, and conformational matching that are the likely keys to their functional presence and essential endosymbiotic activities for over ii.5 billion years.
MeSH Keywords: Chloroplasts, Kleptoplasty, Mitochondria, MTERF, PEWY, Reactive Oxygen Species, Stereospecificity
Background
Mitochondria and chloroplasts correspond endosymbiont models of complex organelle development driven by evolutionary modification of permanently enslaved primordial leaner[1–4]. Over diverse eukaryotic phyla mitochondria and chloroplasts either alone or together provide a concerted amplification of cellular free energy production via shared biochemical pathways. Cellular dysregulation of these 2 distinct organelles may generate potentially dangerous reactive oxygen species (ROS) due to compromised complex bioenergetics free energy product, systemic oxidative stress and compounded pro-inflammatory processes. Chiefly, genetically- or biochemically-mediated failure of mitochondrial function in human populations represents a potentially dire factor in the etiology of major disease states that include Type Two diabetes, atherosclerosis, rheumatoid arthritis, Alzheimer's Disease, and cancer progression [v–21]. In sum, these compelling mechanistic and clinical data suggest that the extent of mitochondrial/chloroplast regulatory signaling may vary over the lifetime of the eukaryotic prison cell according to physiological demand and bioenergetics requirements[22,23].
Interestingly, a tumor cell may exist viewed as a phenotypic reversion to the terminal common eukaryotic ancestor of the host cell, i.e., a facultative anaerobic microbe with unlimited replication potential [24]. For example, anaerobic mitochondria in gill cilia of Chiliad. edulis have evolved to use the phenotype of a facultative anaerobe, demonstrating that this primitive type of respiration has been evolutionarily conserved [25,26]. Accordingly, anaerobically functioning mitochondria may represent a re-emergence or evolutionary retrofit of primordial metabolic processes.
Information technology has become recently apparent that mitochondria take discrete microenvironments composed of complex intracellular membrane structures with distinct functional identities determined by segregated biochemical pathways [27] (Figure 1). Given the shared chemical messengers betwixt the two and interrelationships between the common energy processes it is not surprising that additional commonalities are emerging. Furthermore, it is no surprise that mitochondria are nowadays in both plants and animals, implying major shared regulatory, bioenergetic, and chemical substrate pathways. Commonalities of energy processing in both plants and animals take become fifty-fifty stronger by the finding that chloroplast can exist found in animal cells. The discovery of kleptoplasty, a functional chloroplast in cells of a non-photosynthetic host [28] is a remarkable phenomenon [28–31]. It is also found in metazoans, i.east., the sacoglossan sea slug. Of equal importance is the longevity of functional kleptoplasts in the host, suggesting again the common significance of bidirectional communication and the many commonalities in molecules exist so that this phenomenon can take place and piece of work. These sea slugs excerpt and incorporate functional chloroplasts from Ulvophyceae into their gut cells [32], allowing their derived "food" to be gained for months. The dependence on specific algae strongly suggests common bidirectional advice is responsible for these phenomena.
The prokaryotic cell is characterized past a general lack of highly structured intracellular organelles but displays intracellular regions of functionality with some membrane enhancements, e.g., mesosome. We surmise that with time this relatively simple structure became more elaborate, calculation membrane surface expanse to perform piece of work, enhancing a major function like respiration. In all probability the stimulus was solar energy, causing the photolysis of water. This cell was driven in this direction because it provided a new coping strategy for, counter-intuitively, Deoxyribonucleic acid advancement. This evolving cellular architecture could not survive on its own given the presence of by products it produced, due east.g., ROS, which are basically toxic to unprotected intracellular components, notably DNA. This evolutionary self protection machinery was further advanced when oxygen levels increased as a result of photosynthesis. In all probability the cellular oxygen toxicity event was partly solved by having a "bacterium" develop in a "bacterium", condign a eukaryotic cell, which could harvest specific bond energy. This also aided in ROS protection with a more structured and protected environment for this new intracellular human relationship to evolve, having a plentiful energy supply for novel DNA expression. Accordingly, a major free radical and free radical creator was finer removed via chloroplasts, which originated in a similar manner as mitochondria. Thus, it is non surprising to find both types of "bacteria" in the same prison cell and others where only ane is nowadays. Furthermore, given this close evolvement, enslavement was non an issue in this circumstance because each "cell" used the same or like chemical messengers, stabilizing what appears to be a precarious human relationship. Indeed, bidirectional advice served every bit the procedure for eukaryotic cellular communication/cooperation, which immune for metazoan development. Interestingly, metazoan development is still highly dependent on the intracellular communication with its endogenous bacterial components from which it evolved, e.g., intracellular and extracellular (gut microbiome). The vulnerability expresses itself in "mitochondrial dysfunction" in that information technology can be so complicated and various depending on the tissue region affected. We further surmise that hypoxia plays a major role in triggering mitochondrial dysfunction since this entire relationship depends on a continuously ongoing free energy processing organization[2,21]. Briefly, the evolutionary advocacy of eukaryotic cells requires this homeostatic energy balance to maintain its multicomponent and faceted existence. Any deviation from the thermodynamically stabilized life form creates a pathology wherever information technology occurs. This process may also stand for the deleterious mechanisms that may be associated with aging.
The power of a chloroplast to function as a symbiotic bioenergetic organelle within the intracellular milieu of a representative invertebrate, i.e., the Sacoglossan sea slug, was previously identified every bit a unique phenomenon unlikely to occur in vertebrates [28–32]. Recently, the observation of internalized algae within embryonic tissues of the spotted salamander strongly advise that developmental processes within a vertebrate organism may require photosynthetic endosymbiosis as an internal regulator [33]. Appropriately, it appears that green algae and spotted salamander embryos take an intimate endosymbiotic relationship and algae are able to invade the embryonic tissues and cells of the salamander and somewhen degrade every bit the larvae develop over time [33]. Although endosymbiotic algal cells go through degradation, the cells can also encyst on the inner capsule wall which is detected through 18s rDNA amplification in the reproductive tracts of the adult salamanders, thereby assuasive for the transfer of genes from 1 generation to the next [33]. Due to the dumbo accumulation of algae within the embryo, a distinct green color is exhibited which leads to benign effects for the embryo. Requisite physiological furnishings include lowering embryonic mortality, larger embryo size, and before hatching times. Information technology is still unclear if the algae and the embryo have a true bidirectional symbiotic relationship considering in that location is evidence that the algae have no increase in oxygen levels, but they may do good from the embryos when their nitrogenous waste material is released. In any event, this miracle defines a distinctive relationship betwixt developmental processes in a defined vertebrate organism and eukaryotic algae.
A conscientious test of the biomedical literature has yielded many examples of existential commonalities between mitochondria and chloroplasts, which include gratuitous living bacteria [34]. Formally known as the PEWY motif in mitochondrial complexes, cyt b displays iv tetrapeptide residues (PDWY, PPWF, PVWY and PEWY) employed in catalytic reactions, which is at present identified every bit the Qo motif. PEWY, which is present in chloroplasts and mitochondria, and PDWY which is nowadays in Gram-positive bacteria both associate with the redox potential of quinone species [34]. These data advise that when electron transfer occurs from a low-high potential throughout evolution that the cyt bc1 circuitous with PEWY existence the Qo motif volition part all-time with a high potential and ubiquinone as its substrate [34]. For PDWY as the cyt b circuitous, a low potential and menaquinone will function the best. In sum, the molecular evolution/retention of the catalytic Qo quinol oxidation site of cytochrome b complexes, functionally underlies the common memory of a chemiosmotic proton gradient machinery for ATP synthesis in cellular respiration and photosynthesis.
The relationship between photosynthesis and respiration can vary, thereby demonstrating their dynamic nature. For example, when love apple fruit ripen, their chloroplasts will alter into photosynthetically inactive chromoplasts that can produce ATP through a respiration process known as chromorespiration [35]. Oxygen consumption through chromorespiration tin can exist stimulated past NADH and NADPH, and is also sensitive to the plastidial terminal oxidase inhibitor octyl gallate. Isolated chromoplasts are also sensitive to multiple molecules such equally the cytochrome b 6 f complex inhibitor 2,5-dibromo-three-methyl-6-isoproply-p-benzoquinone [35]. Cytochrome f was identified in the chromoplast as was cytochrome c6 and their expression increases in ripened tomatoes suggesting that they may be acting as electron acceptors for the cytochrome b 6 f complex. During ripening, mitochondrial numbers significantly decrease in the fruit tissue [35]. In guild to compensate for this strong decrease, the number of chromoplasts will functionally increment during the later stages of ripening, thereby demonstrating disquisitional modification of energy processing.
Importantly, plants crave imported oxygen to deport out most of their biochemical reactions such as respiration even though they lack the ability to distribute oxygen to the cells [36]. To recoup for the lack of this distribution machinery, plants often display steep oxygen gradients that may be impaired due to environmental distress [36]. Thus, plants require different physiological responses to manage the variations of oxygen levels available to them and display metabolic adaptations in energy requirements. As a key example, physiological demand is coupled to activation of the cellular glycolytic pathway to generate ATP production when oxidative phosphorylation is compromised [27]. Cellular oxygen levels have been demonstrated to regulate the expression of Group-VII ethylene response factors (ERFs), a family of transcription factors involved in the regulation of hypoxia-inducible genes that include HRE1 and HRE2 [36]. Furthermore, the functional integrity of mitochondria and chloroplasts are critically linked to cellular oxygen requirements, equally regulated by the N-stop rule signaling pathway due to the impacted loss. The Due north-stop rule signaling pathway represents a cellular response mechanism that requires ubiquitin ligation linked to proteasomal degradation via covalent modification of N-terminal amino acids [36].
Finally, the array of complex control mechanism past which organellar gene expression (OGE) promotes respiration, photosynthesis and plant development is actively nether investigation [37]. Soon, several required components have been identified that have been functionally associated with OGE processes. Nucleus-encoded proteins have important roles in OGE by promoting various required functions such as splicing, transcription, RNA processing and regulation of translational processes. Normative OGE is regulated by the family unit of mitochondrial transcription termination factors (mTERF). Mammalian mTERFS were originally proposed to specifically finish transcription, merely further biochemical and molecular studies signal that three out of the four mTERFS possess important regulatory activities necessary for ribosomal biogenesis and antisense transcription termination. Approximately 30 members of the mTERF family unit have been identified throughout found evolution, merely nevertheless little is known about how photosynthetic organisms are using mTERFs and OGE [28]. In sum, the dual regulatory targeting of mitochondrial and chloroplast gene expression by mTERF proteins to promote optimal energy production and oxygen consumption further advances the evolutionary importance of OGE processes.
Conclusions
It is at present established that the same set of functional genes are encoded in both the plastid and mitochondrial genomes, which express the same conserved proteins in the electron transport chain [38]. Thus, it is strongly unsaid that OGE processes are critically linked to shared stereo-selective biochemical pathways. Maier and colleagues refer to this equally an case of parallel and convergent evolution. The ongoing processes underlying biologically meaningful evolutionary modification of the organellar genome tin be partly attributed to regulatory stability of intracellular redox processes. Equally such, a hypothesis of evolutionary modification of intracellular redox regulation predicts that in that location is a specific location for the plastids and mitochondria genes that encode for bioenergetics membrane proteins that are functionally related to respiration or photosynthesis [38]. The dual evolution of the plastid and mitochondria genomes will effectively bulldoze the retentiveness of functionally like sets of ribosomal protein genes which are functionally required for proper ribosomal assembly.
Information technology has been recently proposed that archaebacterium and eubacterium precursors led to the origin of eukaryotes [39,twoscore]. Conversely, mitochondria arose from an blastoff-proteobacterium and a eukaryote [forty,41]. Plastids arose in a similar manner but from cyanobacterium and a eukaryote [40]. Hence the eukaryotic cell was "developed". The developmental primacy of photosynthesis was probably due to abundant sunlight and coincident appearance of requisite photovoltaic chemical processes. Furthermore, the byproducts of these processes, i.eastward., glucose and oxygen, introduced a major modify in the biosphere with the associated evolutionary development of complex cellular respiratory processes and with major potential bug involving oxygen toxicity. In lite of these changes, both photosynthetic and respiratory processes were driven past the potential for bacteria to further raise the intracellular membrane microdomains segregated according to functional physiological criteria.
Appropriately, the respiratory "bacterium" evolved and remained in identify because of its existential brokerage of molecular oxygen and the use of glucose as an initial fuel source in the bioenergetics of ATP production. In this regard, photosynthetic priming events promoted evolutionary acceleration of intracellular membrane differentiation, selective for plastid-like structures. This major contention is supported by the observation that many organelles can be plant in both plant and animal cells and that their molecular biology/bioenergetics share basic chemic processes.
The dual expression of mitochondria and functional chloroplasts within specialized beast cells indicates a loftier degree of biochemical identity, stereoselectivity, and conformational matching that are the likely keys to their functional presence and essential endosymbiotic activities for over ii.5 billion years [3,42–44]. Thus, conformational matching imposes a high degree of rigidity on the systems, allowing for their retention in evolution. Another component of the conformational matching hypothesis is that this phenomenon also occurs via a chemical messenger and its receptor with the added fact that both must be expressed simultaneously and appropriately on the right target [3,42–44]. Therefore, all the conformational dependent substrates and enzymes impose a rigidity on change in general, which does not favor change. However, change can and does occur because slight changes may exist tolerated, giving ascent to modified systems, east. g., the catecholamine pathway.
Footnotes
Conflict of interests
The authors declare no conflict of interests.
Source of support: The report was, in part, funded by MitoGenetics, LLC (Sioux Falls, Due south Dakota)
References
1. Stefano GB, Kream RM. Psychiatric disorders involving mitochondrial processes. Psychology Observer. 2015;1:ane–6. [Google Scholar]
2. Stefano GB, Mantione KJ, Casares FM, Kream RM. Anaerobically functioning mitochondria: Evolutionary perspective on modulation of free energy metabolism in Mytilus edulis. Invertebrate Survival Journal. 2015;12:22–28. [Google Scholar]
3. Snyder C, Stefano GB. Mitochondria and chloroplasts shared in animal and plant tissues: significance of communication. Med Sci Monit. 2015;21:1507–11. [PMC complimentary commodity] [PubMed] [Google Scholar]
4. Mantione KJ, Kream RM, Stefano GB. Variations in disquisitional morphine biosynthesis genes and their potential to influence human health. Neuro Endocrinol Lett. 2010;31:11–18. [PubMed] [Google Scholar]
five. Aliev K, Priyadarshini M, Reddy VP, et al. Oxidative stress mediated mitochondrial and vascular lesions as markers in the pathogenesis of Alzheimer disease. Curr Med Chem. 2014;21:2208–17. [PubMed] [Google Scholar]
6. Carvalho C, Machado N, Mota PC, et al. Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies. J Alzheimers Dis. 2013;35:623–35. [PubMed] [Google Scholar]
7. Chong ZZ, Li F, Maiese K. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative illness. Prog Neurobiol. 2005;75:207–46. [PubMed] [Google Scholar]
8. Ebadi M, Govitrapong P, Sharma South, et al. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease. Biol Signals Recept. 2001;10:224–53. [PubMed] [Google Scholar]
9. Kream RM, Mantione KJ, Casares FM, Stefano GB. Impaired expression of ATP-bounden cassette transporter genes in diabetic ZDF rat blood. International Journal of Diabetes Research. 2014;three:49–55. [Google Scholar]
x. Kream RM, Mantione KJ, Casares FM, Stefano GB. Concerted dysregulation of 5 major classes of blood leukocyte genes in diabetic ZDF rats: A working translational profile of comorbid rheumatoid arthritis progression. International Journal of Prevention and Treatment. 2014;3:17–25. [Google Scholar]
11. Wang F, Guo 10, Shen X, et al. Vascular dysfunction associated with type 2 diabetes and Alzheimer'southward disease: A potential etiological linkage. Med Sci Monit Bones Res. 2014;twenty:118–29. [PMC free article] [PubMed] [Google Scholar]
12. Wang F, Stefano GB, Kream RM. Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: Etiological contribution to Complex Regional Pain Syndromes (Part I) Med Sci Monit. 2014;20:1067–77. [PMC free article] [PubMed] [Google Scholar]
xiii. Wang F, Stefano GB, Kream RM. Epigenetic modification of DRG neuronal gene expression subsequent to nervus injury: Etiological contribution to Complex Regional Pain Syndromes (Part II) Med Sci Monit. 2014;20:1188–200. [PMC free article] [PubMed] [Google Scholar]
xiv. Panksepp J, Herman B, Conner R, et al. The biology of social attachments: sopiates convalesce separation distress. Biol Psychiatry. 1978;thirteen:607–18. [PubMed] [Google Scholar]
fifteen. Pierce RC, Kumaresan V. The mesolimbic dopamine system: The final common pathway for the reinforcing effect of drugs of corruption? Neurosci Biobehav Rev. 2006;xxx:215–38. [PubMed] [Google Scholar]
xvi. Schmauss C, Emrich HM. Dopamine and the action of opiates: a reevaluation of the dopamine hypothesis of schizophrenia. With special consideration of the role of endogenous opioids in the pathogenesis of schizophrenia. Biol Psychiatry. 1985;twenty:1211–31. [PubMed] [Google Scholar]
17. Stepien A, Stepien K, Wlazel RN, et al. Assessment of the human relationship between lipid parameters and obesity indices in non-diabetic obese patients: a preliminary report. Med Sci Monit. 2014;xx:2683–88. [PMC free article] [PubMed] [Google Scholar]
xviii. Gohring I, Sharoyko VV, Malmgren S, et al. Chronic high glucose and pyruvate levels differentially bear on mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/thirteen cells. J Biol Chem. 2014;289:3786–98. [PMC gratis commodity] [PubMed] [Google Scholar]
19. Mantione KJ, Kream RM, Kuzelova H, et al. Comparison bioinformatic gene expression profiling methods: Microarray and RNA-Seq. Med Sci Monit Basic Res. 2014;twenty:138–41. [PMC gratuitous article] [PubMed] [Google Scholar]
xx. Kram KE, Finkel SE. Civilization volume and vessel bear upon long-term survival, mutation frequency, and oxidative stress of Escherichia coli. Appl Environ Microbiol. 2014;fourscore:1732–38. [PMC free article] [PubMed] [Google Scholar]
21. Stefano GB, Kream RM. Hypoxia defined as a common culprit/initiation factor in mitochondrial-mediated proinflammatory processes. Med Sci Monit. 2015;21:1478–84. [PMC gratuitous article] [PubMed] [Google Scholar]
22. Guo R, Li West, Liu B, et al. Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro. Med Sci Monit Basic Res. 2014;20:82–92. [PMC free article] [PubMed] [Google Scholar]
23. Yildirim V, Doganci S, Yesildal F, et al. Sodium nitrite provides angiogenic and proliferative effects in vivo and in vitro. Med Sci Monit Basic Res. 2015;21:41–46. [PMC free article] [PubMed] [Google Scholar]
24. Davila AF, Zamorano P. Mitochondria and the evolutionary roots of cancer. Phys Biol. 2013;10:026008. [PubMed] [Google Scholar]
25. Doeller JE, Grieshaber MK, Kraus DW. Chemolithoheterotrophy in a metazoan tissue: thiosulfate production matches ATP need in ciliated mussel gills. J Exp Biol. 2001;204:3755–64. [PubMed] [Google Scholar]
26. Doeller JE, Kraus DW, Shick JM, Gnaiger Due east. Estrus flux, oxygen flux, and mitochondrial redox land as a function of oxygen availability and ciliary activity in excised gills of Mytilus edulis. J Exp Zool. 1993;265:1–8. [PubMed] [Google Scholar]
27. Tan DX, Manchester LC, Liu X, et al. Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary office and development in eukaryotes. J Pineal Res. 2013;54:127–38. [PubMed] [Google Scholar]
28. Cruz South, Calado R, Serodio J, Cartaxana P. Crawling leaves: photosynthesis in sacoglossan sea slugs. J Exp Bot. 2013;64:3999–4009. [PubMed] [Google Scholar]
29. Serodio J, Cruz S, Cartaxana P, Calado R. Photophysiology of kleptoplasts: photosynthetic use of light by chloroplasts living in animal cells. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130242. [PMC free commodity] [PubMed] [Google Scholar]
30. de Vries J, Christa G, Gould SB. Plastid survival in the cytosol of animal cells. Trends Plant Sci. 2014;19:347–50. [PubMed] [Google Scholar]
31. Pennisi E. Microbiology. Mod symbionts inside cells mimic organelle evolution. Scientific discipline. 2014;346:532–33. [PubMed] [Google Scholar]
32. Handeler K, Wagele H, Wahrmund U, et al. Slugs' final meals: molecular identification of sequestered chloroplasts from dissimilar algal origins in Sacoglossa (Opisthobranchia, Gastropoda) Mol Ecol Res. 2010;ten:968–78. [PubMed] [Google Scholar]
33. Kerney R, Kim E, Hangarter RP, et al. Intracellular invasion of green algae in a salamander host. Proc Natl Acad Sci USA. 2011;108:6497–502. [PMC free article] [PubMed] [Google Scholar]
35. Renato M, Pateraki I, Boronat A, Azcon-Bieto J. Lycopersicon esculentum fruit chromoplasts behave equally respiratory bioenergetic organelles during ripening. Plant Physiol. 2014;166:920–33. [PMC free article] [PubMed] [Google Scholar]
36. van Dongen JT, Licausi F. Oxygen sensing and signaling. Annu Rev Establish Biol. 2015;66:345–67. [PubMed] [Google Scholar]
37. Kleine T, Leister D. Emerging functions of mammalian and plant mTERFs. Biochim Biophys Acta. 2015;1847(ix):786–97. [PubMed] [Google Scholar]
38. Maier UG, Zauner Due south, Woehle C, et al. Massively convergent evolution for ribosomal protein gene content in plastid and mitochondrial genomes. Genome Biol Evol. 2013;5:2318–29. [PMC free commodity] [PubMed] [Google Scholar]
39. Otten AB, Smeets HJ. Evolutionary divers role of the mitochondrial DNA in fertility, illness and ageing. Hum Reprod Update. 2015 [Epub alee of print] [PubMed] [Google Scholar]
40. Hedges SB, Chen H, Kumar S, et al. A genomic timescale for the origin of eukaryotes. BMC Evol Biol. 2001;1:4. [PMC free article] [PubMed] [Google Scholar]
41. Xavier JM, Rodrigues CM, Sola S. Mitochondria: Major regulators of neural development. Neuroscientist. 2015 [Epub ahead of print] [PubMed] [Google Scholar]
42. Stefano GB. Conformational matching: a possible evolutionary force in the evolvement of signal systems. In: Stefano GB, editor. CRC Handbook of comparative opioid and related neuropeptide mechanisms. Vol. ii. Boca Raton: CRC Printing Inc; 1986. pp. 271–77. [Google Scholar]
43. Stefano GB. The evolvement of signal systems: conformational matching a determining force stabilizing families of signal molecules. Comp Biochem Physiol C. 1988;90:287–94. [PubMed] [Google Scholar]
44. Stefano GB. Stereospecificity equally a determining force stabilizing families of signal molecules within the context of evolution. In: Stefano GB, Florey Eastward, editors. Comparative aspects of Neuropeptide Function. Manchester: Academy of Manchester Printing; 1991. pp. 14–28. [Google Scholar]
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